MyBioSource.com's Anti-IDH2 Antibody (monoclonal, 2D4) is a Mouse monoclonal antibody. The Anti-IDH2 Antibody (monoclonal, 2D4) was generated using IDH2, and isocitrate dehydrogenase (NADP(+)) 2 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Cell Sorting, Isolation, Flow Cytometry, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants